CARDIOSIM | Coronary Network 3

Coronary Network 3 and Systemic Arterial Section Modelled with 4-MW.

In the electric analogue the coronary bed is considered as a single branch which links the left ventricular output with the right atrium input. The model which quantitatively describes the basic phenomena, observed in coronary circulation, allows simulating pathological conditions, such as coronary stenosis and spasm, and their role in the decrease of cardiac fiber contractility. The natural coronary bed is composed of two main arteries perfusing left and right ventricles; in the model coronary bed is represented by a single arterial path (R_Artery, C_ArteryMicro, R_ArteryMicro) and a single venous path (R_VenousMicro, C_VenousMicro, R_Venous). In the electrical analogue, R_Artery stands for the input resistance of the coronary arteries. C_ArteryMicro, R_ArteryMicro, R_VenousMicro and C_VenousMicro represent the compliance of arterial bed, the arterial and venous capillary resistance and a compliance of venous bed, respectively. R_Venousstands for the resistance of the coronary veins. C_Myocardium represents the myocardium compliance. The driving factor that primarily accounts for the perfusion of the myocardium is the difference between the aortic pressure and the extravascular pressure acting on the coronary vessels, that is the intramyocardial pressure.The left ventricular myocardial pressure is higher in the endocardium and lower in the epicardium. In the model, the intramyocardial pressure refers to the endocardial pressure, considered proportional to the left ventricular pressure (LVP).

Systemic arterial section is modelled with 4-MW, systemic venous compatment is reproduced by 2-MW with variable resistance (Rvs).

In: MODELLING CARDIOVASCULAR SYSTEM AND MECHANICAL CIRCULATORY SUPPORT. Claudio De Lazzari Editor (2007). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-081-1.

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Coronary Network 3 with Aortic, Thoracic and Abdominal Compartments.

The natural coronary bed is composed of two main arteries perfusing left and right ventricles; in the model coronary bed is represented by a single arterial path (R_Artery, C_ArteryMicro, R_ArteryMicro) and a single venous path (R_VenousMicro, C_VenousMicro, R_Venous). In the electrical analogue, R_Artery stands for the input resistance of the coronary arteries. C_ArteryMicro, R_ArteryMicro, R_VenousMicro and C_VenousMicro represent the compliance of arterial bed, the arterial and venous capillary resistance and a compliance of venous bed, respectively. R_Venousstands for the resistance of the coronary veins. C_Myocardium represents the myocardium compliance. The driving factor that primarily accounts for the perfusion of the myocardium is the difference between the aortic pressure and the extravascular pressure acting on the coronary vessels, that is the intramyocardial pressure.The left ventricular myocardial pressure is higher in the endocardium and lower in the epicardium. In the model, the intramyocardial pressure refers to the endocardial pressure, considered equal to the left ventricular pressure.

Systemic arterial section is modelled with two RLC elemets (aortic and thoracic compartments), one 4-MW element (abdominal tract) and one RC element (venous section). Systemic peripheral resistance (Ras) and systemic venous resistance (Rvs) are both variable resistances. The coronary model is connected between the aortic pressure (AoP) and the rigt atrial pressure (RAP).

In: MODELLING CARDIOVASCULAR SYSTEM AND MECHANICAL CIRCULATORY SUPPORT. Claudio De Lazzari Editor (2007). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-081-1.

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Coronary Network 3 with Complex Systemic Circulation Model.

The natural coronary bed is composed of two main arteries perfusing left and right ventricles; in the model coronary bed is represented by a single arterial path (R_Artery, C_ArteryMicro, R_ArteryMicro) and a single venous path (R_VenousMicro, C_VenousMicro, R_Venous). In the electrical analogue, R_Artery stands for the input resistance of the coronary arteries. C_ArteryMicro, R_ArteryMicro, R_VenousMicro and C_VenousMicro represent the compliance of arterial bed, the arterial and venous capillary resistance and a compliance of venous bed, respectively. R_Venousstands for the resistance of the coronary veins. C_Myocardium represents the myocardium compliance. The driving factor that primarily accounts for the perfusion of the myocardium is the difference between the aortic pressure and the extravascular pressure acting on the coronary vessels, that is the intramyocardial pressure.The left ventricular myocardial pressure is higher in the endocardium and lower in the epicardium. In the model, the intramyocardial pressure refers to the endocardial pressure, considered equal to the left ventricular pressure.

Systemic circulation is described in Systemic Network 6.

In: MODELLING CARDIOVASCULAR SYSTEM AND MECHANICAL CIRCULATORY SUPPORT. Claudio De Lazzari Editor (2007). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-081-1.

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Equations Solving the Coronary Network 3.

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Circulatory Models

Coronary Network 3