CARDIOSIM | Thoracic Artificial Lung

In Serie, in Parallel and in Hybrid Mode Connection of Thoracic Artificial Lung (TAL) to the Pulmonary Circulation.

The thoracic artificial lung model was implemented using a lumped parameter model (see following slide). The TAL is connected between the right ventricular output and the pulmonary circulation. The connection to the pulmonary circulation can be realised in series, in parallel or in a hybrid mode. In the hybrid mode TAL input is connected to the right ventricular output. Outlet flow from the hybrid TAL is split between two grafts: the first one outlet graft is connected to the pulmonary circulation through the resistance (R_TALpab); the second one is linked to the left atrium through the RL element R_TALala and L_TALala. These resistances permit to divide the blood flow between the TAL and the pulmonary circulation. The hybrid mode enables sufficient levels of blood flow to both natural and TAL, while maintaining an intermediate load to the right ventricle. In-series mode can be implemented setting the resistances R_TALpab and R_TALala to infinity value. Finally, parallel configuration can be realized setting the resistance R_TALan (see following slide) to infinity value.

In: C. De Lazzari, I. Genuini, et al. (2014). Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study. Computer Methods and Programs in Biomedicine, 113 (2), 642-654. https://dx.doi.org/doi:10.1016/j.cmpb.2013.11.011

In: CONCEPT, MATHEMATICAL MODELLING AND APPLICATIONS IN HEART FAILURE. Massimo Capoccia and Claudio De Lazzari Eds. (2019). Published by Nova Science Publishers, Inc. New York. ISBN 978-1-53614-771-1.

In: CARDIOVASCULAR AND PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. Claudio De Lazzari and Marina Pirckhalava Eds. (2017). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-240-2.

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Electrical Analogue of Thoracic Artificial Lung (TAL).

Electric analogue is described using RLC elements: L_TALin, L_TALala and L_TALan modelled the inertia in the grafts (they depend on the blood density, the graft radius and the graft length; C_TALad (C_TALap) represents the TAL inlet (outlet) chamber; C_TALin (R_TALin) is the inlet compliance (resistance) of the TAL; R_TALpab and R_TALala are two resistances used to divide the flow between the pulmonary artery (R_TALpab) and the left atrium (R_TALala); R_TALad (R_TALap) are the flow dependent inlet (outlet) resistance; R_TALan is the outlet graft resistance to the pulmonary artery.

In: C. De Lazzari, I. Genuini, et al. (2014). Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study. Computer Methods and Programs in Biomedicine, 113 (2), 642-654. https://dx.doi.org/doi:10.1016/j.cmpb.2013.11.011

In: CONCEPT, MATHEMATICAL MODELLING AND APPLICATIONS IN HEART FAILURE. Massimo Capoccia and Claudio De Lazzari Eds. (2019). Published by Nova Science Publishers, Inc. New York. ISBN 978-1-53614-771-1.

In: CARDIOVASCULAR AND PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. Claudio De Lazzari and Marina Pirckhalava Eds. (2017). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-240-2.

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Electrical analogue of Thoracic Artificial Lung (TAL) and Cardiocirculatory Network.

In the slide are plotted different cardiocirculatory sections with TAL. Heart section consists of left and right ventricles, left and right atria and the septum. All these elements are described by variable elastance model; elv (erv) represents the left (right) ventricular time-varying elastance; ela (era) is the left (right) atrial time-varying elastance; e_V-SPT (e_A-SPT) represents the time-varying interventricular (interatrial) septum (see the Numerical Heart Model (2) section). AT, TT and ABT are the aortic, thoracic and abdominal tracts respectively. SV is systemic thoracic vein section. MPA (SPA) is the mean (small) pulmonary artery section. PA (PC) is the pulmonary arteriole (capillary) section. MV, AV, PV and TV are the mitral, aortic, pulmonary and tricuspid valves respectively. TAL section is described by: L_TALin, L_TALala and L_TALan modelled the inertia in the grafts (they depend on the blood density, the graft radius and the graft length; C_TALad (C_TALap) represents the TAL inlet (outlet) chamber; C_TALin (R_TALin) is the inlet compliance (resistance) of the TAL; R_TALpab and R_TALala are two resistances used to divide the flow between the pulmonary artery (R_TALpab) and the left atrium (R_TALala); R_TALad (R_TALap) are the flow dependent inlet (outlet) resistance; R_TALan is the outlet graft resistance to the pulmonary artery.

In: C. De Lazzari, I. Genuini, et al. (2014). Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study. Computer Methods and Programs in Biomedicine, 113 (2), 642-654. https://dx.doi.org/doi:10.1016/j.cmpb.2013.11.011

In: CONCEPT, MATHEMATICAL MODELLING AND APPLICATIONS IN HEART FAILURE. Massimo Capoccia and Claudio De Lazzari Eds. (2019). Published by Nova Science Publishers, Inc. New York. ISBN 978-1-53614-771-1.

In: CARDIOVASCULAR AND PULMONARY ARTIFICIAL ORGANS: EDUCATIONAL TRAINING SIMULATORS. Claudio De Lazzari and Marina Pirckhalava Eds. (2017). Published by Consiglio Nazionale delle Ricerche (CNR) ROMA. ISBN 978-88-8080-240-2.

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